These are some of the most widely used drugs in the world. First-generation antihistamines include:įirst-generation antihistamines are in many over-the-counter (OTC) flu and cold medicines, such as Nyquil or Advil PM. First-generation antihistaminesįirst-generation antihistamines (developed more than 60 years ago) commonly cause sleepiness. Antihistamines help reduce allergy symptoms caused by environmental, seasonal, or food allergies. They reduce or block the histamines, preventing allergic reaction symptoms. When produced, histamines cause an allergic reaction with symptoms including stuffy nose hives and skin rashes or itchiness of the throat, eyes, or nose.Īntihistamines are medicines that are typically cheap and available over the counter. What are antihistamines?Īllergies happen when allergens-such as pollen, pet dander, peanuts, mosquito bites, or ragweed-trigger chemicals in the body called histamines. Luckily for those wanting to avoid drowsiness, there are a variety of non-drowsy alternatives. Antihistamines that cause drowsiness can increase the risk of falls for people over the age of 65. Due to the severity of drowsiness, some people take Benadryl as a sleep aid, which may lead to sleepwalking. Drowsiness from antihistamines can cause reduced coordination and reaction speed, making driving and operating machinery more dangerous. However, sometimes the side effect of drowsiness can be just as bad as the symptoms they are treating. Typically, 'Non-drowsy' Benadryl simply refers to alternative antihistamines (like Claritin and Allegra), that do not cause drowsiness.Antihistamines, like Benadryl, are one of the best treatments when it comes to alleviating the symptoms of allergies and colds.There is no such product as 'non-drowsy' Benadryl.Other potential side effects of antihistamines include: Non-sedating, however Zyrtec has been shown to causeĪt least some drowsiness (as stated above). Second-generation antihistamines are generally Second generation antihistamines include: The first generation antihistamines areĪlso listed as medications to avoid in elderly adults by the Beers Criteriaĭue to the increased risk of confusion, dry mouth, and drowsiness. First generation antihistamines can also cause urinary Other first generation antihistamines include:įirst-generation antihistamines cross the blood-brain barrier and have CNS effects like drowsiness andĭizziness. Sedating than the second-generation class of antihistamines. To be a first-generation antihistamine which are generally known to be more Symptoms including runny nose, watery eyes, sneezing, and itching of the nose, Antihistamine MedicationĪntihistamines are widely used for self-care of allergy Antihistamines are useful in preventing the immuneĬascade so common in people suffering from allergies. Some people are more sensitive to this response and may not even know what HistamineĬan be triggered by a variety of things including pollen, dust, and pet dander. Immune response to essentially attempt to remove the offensive allergen. If and when histamine does bind to their respective receptors, it creates an Byīinding and changing the shape of the histamine receptor, antihistamines The nose, lungs, eyes, and skin without activating the histamine response. It still is far less than the sedation caused by Benadryl.Īntihistamines work by binding to histamine receptors that are found in "Second-generation" antihistamines include:Īllegra and Claritin are considered non-drowsy while Zyrtec has around a 5-15% incidence of drowsiness. Most are classified as 'non-drowsy' and can last up to 24 hours per dose. If you are looking for a non-drowsy allergy medication, "second-generation" antihistamines are your best bet. Depending on what youĪre using the Benadryl for, you may be able to substitute other over-the-counter 'Non-drowsy Benadryl' simply refers to an alternative antihistamine that is not diphenhydramine. Simply put, there is no special formulation of diphenhydramine that won't cause drowsiness. Special formulations of Benadryl that are non-drowsy, there are alternativeĪntihistamines that are less likely to cause drowsiness. It is a common misunderstanding that there is a 'non-drowsy' form of Benadryl, but there unfortunately is no such product. Answerīenadryl, also known by its generic name diphenhydramine, isĪn antihistamine that does commonly cause drowsiness. Is there such a thing? Benadryl works great for me but it does make me tired. I've heard of non-drowsy Benadryl but can't find it anywhere.
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